CXCL10 (pig) ELISA kit

Assay Kits - ELISA

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Cat No: A05419

Assay Kits - Elisa

Enzyme ImmunoAssay (EIA) is a technique to detect and quantify antigens (proteins, hormones…) or antibodies in samples. It relies on the ability of an antibody to bind a specific antigen. Either the antibody or the antigen is labelled with an enzyme wh...

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                        Territorial Availability: Available worldwide directly through Bertin or your local distributor
                    

                                            Technical Warning: Check the Additional Items Required section of this kit booklet to verify if UltraPure Water (Milli-Q or equivalent) is needed for this assay
                    

Synonyms:

IP-10

C-X-C motif chemokine ligand 10

C-X-C motif chemokine 10

Correlated keywords:

ELISA

Cancer

Inflammatory

Chemokines

Swine

Porc

Product Overview:
Enzyme ImmunoAssay (EIA) is a technique to detect and quantify antigens (proteins, hormones…) or antibodies in samples. It relies on the ability of an antibody to bind a specific antigen. Either the antibody or the antigen is labelled with an enzyme whose substrate is a chromogen or a fluorogen converted in a measurable product (color or fluorescence).
Enzyme-linked Immunosorbent Assay (ELISA) is a type of EIA using a solid phase (ex: microtiter plate) coated with an antigen immobilizing the molecule to detect. Over the time, scientists have extended the term ELISA to EIAs using an antibody coating the solid phase. That explains why our EIA kits using coated antibodies are also called ELISA kits.
CXCL10 is also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 with a molecular weight close to 10 kDa. CXCL10 is expressed by several cellular types like monocytes, endothelial cells and fibroblasts stimulated by the interferon-gamma (INF-γ). The receptor of this chimiokine is CXCR3 that is shared with CXCL9 and CXCL11. CXCL-10 plays an important role in the recruitment of the immune cells to sites of inflammation. It is included in physiological process like bone marrow colony formation and angiogenesis but also in some disorders like Th1-type human inflammatory diseases, or cancer.

Size	96 wells
Shipping	wet ice
Specificity	refer to technical booklet
Application Media	It is the responsibility of the user to check the compatibility of the assay with the study matrix
Sample volume	100 µL
Tracer	horseradish peroxidase HRP
Detection Limit	≤0,08 ng/mL
Standard Curve Range	0,08-10,00 ng/mL
Custom Code	3822000000
UNSPSC code	41116104

Luster A. D., Unkeless J. C., Ravetch J. V. Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. 1985 Nature 315:672.

Booth V,. Keizer D.W., Kamphuis M.B., et al. The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. 2002 Biochemistry. 41 (33): 10418–25.

Dufour J. H., Dziejman M., Liu M. T., et al. IFN-γ-Inducible Protein 10 (IP-10; CXCL10)-Deficient Mice Reveal a Role for IP-10 in Effector T Cell Generation and Trafficking. 2002 J Immunol 168:3195-3204

Gottlieb, A. B., Luster A. D., Posnett D. N., et al. Detection of a γ-interferon-induced protein IP-10 in psoriatic plaques. 1988 J. Exp. Med. 168:941-948.

Angiolillo A.L., Sgadari C., Taub D.D., et al. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. 1995 The Journal of Experimental Medicine. 182 (1): 155–162.

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