Timosaponin AIII

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Timosaponin AIII

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Cat No: 22236

Biochemicals - Natural Products

Timosaponin AIII (TAIII) is a steroidal saponin isolated from A. asphodeloides that has anticancer, anti-inflammatory, and antithrombotic activities and also improves learning and memory deficits in mice.{36060,36061,36062,36063,36064} It inhibits inv...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3?,5?,25S)-spirostan-3-yl 2-O-?-D-glucopyranosyl-?-D-galactopyranoside

Correlated keywords:

11032-27-2 139077-63-7 anemarsaponin A3 A-3 filiferin B xilingsaponin A zhi-mu saponin anemarrhena anti-cancer antiinflammatory anti-thrombotic COX2 MDAMB-231 MDAMB231 B16F10 NFkB IL1b TNFa IL6 TA-III MPO interleukin cyclooxygenase

Product Overview:
Timosaponin AIII (TAIII) is a steroidal saponin isolated from A. asphodeloides that has anticancer, anti-inflammatory, and antithrombotic activities and also improves learning and memory deficits in mice.{36060,36061,36062,36063,36064} It inhibits invasive activity and COX-2 gene expression induced by hepatocyte growth factor (HGF) in MDA-MB-231 breast cancer cells and B16-F10 melanoma cells in a concentration-dependent manner.{36063,36064} TAIII (25 mg/kg) significantly reduces the number of metastatic nodules in B16-F10 melanoma cell-treated mice.{36063} Oral administration of TAIII reduces 2,3,4-trinitrobenzene sulfonic acid-induced colon shortening, myeloperoxidase activity, NF-kB activation, and IL-1β, TNF-α, and IL-6 levels in mice.{36061} TAIII reduces mortality and venous thrombus weight in mice with acute thromboembolism.{36062} It inhibits acetylcholinesterase in vitro (AChE; IC50 = 35.4 μM) and improves scopolamine-induced learning and memory deficits in mice, as measured using the passive avoidance test and Morris water maze.{36060}

Size	1 mg
Shipping	dry ice
CAS Number	41059-79-4
Molecular Formula	C₃₉H₆₄O₁₃
SMILES	O[C@H]([C@H](O)[C@H]1O[C@@]2([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)[C@@H](CO)O[C@@]1([H])O[C@H]3CC[C@@]4(C)[C@@](CC[C@]5([H])[C@]4([H])CC[C@@]6(C)[C@@]5([H])C[C@@]7([H])[C@]6([H])[C@H](C)[C@]8(OC[C@@H](C)CC8)O7)([H])C3
Molecular Weight	740,9
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2909.30
UNSPSC code	12352100

Technical File

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.