Hederacoside C

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Hederacoside C

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Cat No: 25138

Biochemicals - Natural Products

Hederacoside C is a saponin that has been found in K. pictus and has anti-inflammatory activity.{36806,36808} It is an inhibitor of acetylcholinesterase (AChE; IC50 = 31.3 μM).{36808} Hederacoside C (0.5-5 μg) inhibits mutagenicity induced by aflatoxi...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3?-[[2-O-(6-deoxy-?-L-mannopyranosyl)-?-L-arabinopyranosyl]oxy]-23-hydroxy-olean-12-en-28-oic acid, O-6-deoxy-?-L-mannopyranosyl-(1?4?)-O-?-D-glucopyranosyl-(1?6)-?-D-glucopyranosyl ester

Correlated keywords:

27013-76-9 52038-14-9 52229-78-4 56292-18-3 94021-48-4 103470-80-0 104748-89-2 1002105-94-3 1407838-40-7 kalopanax antiinflammatory B-1 Salmonella TNF? IL1? IL6 COX2 cyclooygenase umor necrosis factor IL1 IRAK-1 lipopolysaccharide Clematangoside A Glycoside L-H2 Hederoside H1 Koronaroside B Tauroside

Product Overview:
Hederacoside C is a saponin that has been found in K. pictus and has anti-inflammatory activity.{36806,36808} It is an inhibitor of acetylcholinesterase (AChE; IC50 = 31.3 μM).{36808} Hederacoside C (0.5-5 μg) inhibits mutagenicity induced by aflatoxin B1 (Item No. 11293) in S. typhimurium agar cultures from 21 to 67%.{36807} It reduces TNF-α, IL-1β, IL-6, COX-2, and nitric oxide synthase (NOS) levels in a concentration-dependent manner and IL-1 receptor-associated kinase-1 (IRAK1) activity in isolated mouse peritoneal macrophages stimulated by LPS when used at concentrations ranging from 5 to 10 μM.{36806} Hederacoside C (0.02 mg/kg) reduces carrageenan-induced hind paw edema by 37% compared to vehicle control in a rat model of acute inflammation.{36809} It reduces scopolamine-induced memory impairment and increases latency in a passive avoidance test and spontaneous alteration in a Y-maze in mice by 100 and 59%, respectively, when administered at a dose of 40 mg/kg.{36808} Hederacoside C (5 mg/kg, i.p.) reduces serum levels of TNF-α and IL-1β in LPS-challenged mice by 60 and 65%, respectively.{36806}

Size	10 mg
Shipping	dry ice
CAS Number	14216-03-6
Molecular Formula	C₅₉H₉₆O₂₆
SMILES	CC1(C)CC[C@]2(C(O[C@@H]3O[C@H](CO[C@H]4[C@H](O)[C@@H](O)[C@H](O[C@@]5([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@@H](CO)O4)[C@@H](O)[C@H](O)[C@H]3O)=O)CC[C@@]6(C)[C@]7(C)CC[C@@]8([H])[C@@](CO)(C)[C@@H](O[C@]9([H])OC[C@H](O)[C@H](O)[C@H]9O[C@@]%10([H])[C@H
Molecular Weight	1221,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.