Saikosaponin A

Saikosaponin A

CAT N°: 25026
Price:

From €55.00 €46.75

Saikosaponin A is a triterpenoid saponin with diverse biological activities, including anti-inflammatory, antiallergic, anticonvulsive, antiproliferative, and antiviral properties.{34440,42259,42260,42262} Saikosaponin A reduces expression of TNF-?, IL-6, and IL-1? in primary mouse macrophages stimulated by LPS.{42257} It also increases the survival rate in mice with LPS-induced lethal endotoxemia in a dose-dependent manner.{42257} Saikosaponin A (20 mg/kg, i.v., per day) reduces weight loss, brain edema, blood-brain barrier disruption, and IL-6 and TNF-? protein levels in the ipsilateral cortex compared to control animals in a rat model of traumatic brain injury.{42258} It also reduces the number of nasal rubs and levels of serum TNF-? in an ovalbumin-sensitized allergic rhinitis mouse model in vivo when administered at a dose of 8 mg/kg.{42259} It reduces the duration and frequency of epileptiform activity in rat hippocampal CA1 neurons in a dose-dependent manner in a 4-aminopyridine (4-AP; Item No. 18511) seizure model.{42260} Saikosaponin A (20 µM) decreases viability in six human colon carcinoma (HCC), H358 lung and MCF-7 breast cancer, as well as Jurkat and K582 leukemia cell lines.{42261} It also prolongs tumor growth inhibition in LoVo and SW480 HCC mouse xenograft models in vivo when used at a dose of 2 mg/kg.

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