Hecogenin

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Hecogenin

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Cat No: 21372

Biochemicals - Lipids

Hecogenin is a natural steroid sapogenin with diverse biological activities that was originally isolated from A. sisalana and has been used in the synthesis of steroids.{38813} It has antioxidant, anti-inflammatory, antiproliferative, and neuroprotec...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3?,5?,25R)-3-hydroxy-spirostan-12-one

Correlated keywords:

1368-00-9 27067-83-0 gekogenin hekogenin hocogenin NSC115921 antiinflammatory anti-proliferative oxidant Agave MDAMB-231 468 MCF10A MCF7 T-47D BT-474 MDAMB231 MDAMB468 12-Oxotigogenin SKBR3

Product Overview:
Hecogenin is a natural steroid sapogenin with diverse biological activities that was originally isolated from A. sisalana and has been used in the synthesis of steroids.{38813} It has antioxidant, anti-inflammatory, antiproliferative, and neuroprotective properties.{38814,38815,38816,38817} Hecogenin (10 μM) decreases superoxide anion formation induced by N-Formyl-Met-Leu-Phe (fMLP; Item No. 21495) in rat neutrophils by 23.6%.{38814} It also inhibits myeloperoxidase (MPO) release from human neutrophils activated by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) when used at a concentration of 1 μg/ml.{38815} Hecogenin inhibits proliferation of the breast cancer cell lines MDA-MB-231, MDA-MB-468, MCF-10A, MCF-7, T47D, BT474, and SK-BR-3 (IC50s = 28.7-38.2 μM).{38816} It decreases the number of glutamate-induced TUNEL-positive primary rat spinal motor neurons by 11% when used at a concentration of 1 μM.{38817} In vivo, hecogenin (15 mg/kg) decreases the mucosal lesion area of ethanol-induced gastric ulceration in mice.{38815} It also decreases tumor volume in an MDA-MB-231 human breast cancer mouse xenograft model when administered at a dose of 10 mg/kg three times per week.{38816}

Size	100 mg
Shipping	dry ice
CAS Number	467-55-0
Molecular Formula	C₂₇H₄₂O₄
SMILES	O=C1[C@@]2(C)[C@](C[C@@]3([H])[C@]2([H])[C@H](C)[C@]4(OC[C@H](C)CC4)O3)([H])[C@]5([H])CC[C@@]6([H])C[C@@H](O)CC[C@]6(C)[C@@]5([H])C1
Molecular Weight	430,6
Formulation	A crystalline solid
Purity	≥80%
Custom Code	2932.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.