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13,14-dihydro-15-keto Prostaglandin E2-d4

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    13,14-<wbr/>dihydro-<wbr/>15-<wbr/>keto Prostaglandin E<sub>2</sub>-<wbr/>d<sub>4</sub>
  • 13,14-<wbr/>dihydro-<wbr/>15-<wbr/>keto Prostaglandin E<sub>2</sub>-<wbr/>d<sub>4</sub>
Cat No: 10010606
Biochemicals - Isotopically Labeled Standards
Cayman
€124.00
Price is excluding VAT and does not include packaging neither shipping

13,14-dihydro-15-keto Prostaglandin E2-d4 (13,14-dh-15-keto PGE2-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dh-15-keto PGE2 (Item No. 14650) by GC...

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 9,15-dioxo-11α-hydroxy-prost-5Z-en-1-oic-3,3,4,4-d4 acid
Correlated keywords:
  • deuterated metabolites 13,14-dihydro-15-keto-PGE2 prostaglandins PGE2 deuterium
Product Overview:
13,14-dihydro-15-keto Prostaglandin E2-d4 (13,14-dh-15-keto PGE2-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dh-15-keto PGE2 (Item No. 14650) by GC- or LC-MS. 13,14-dh-15-keto PGE2 is the primary metabolite of PGE2 (Item No. 14010) in plasma.{182} Endogenous or infused PGE2 is rapidly metabolized by the enzymes 15-hydroxy PGDH and 15-oxo-PG Δ13-reductase to form 13,14-dh-15-keto PGE2. 13,14-dh-15-keto PGE2 accumulates to detectable levels; plasma levels in humans are between 10-100 pg/ml.{433,4383} It undergoes further metabolism and chemical decomposition, giving it a relatively short half-life. In dogs, the plasma half-life of 13,14-dh-15-keto PGE2 is about 9 minutes.{433} In humans the metabolite has a similar short half-life, making it a poor choice of analytes for assays designed to measure total PGE2 biosynthesis.{366,581}
Size 25 µg
Shipping dry ice
Stability Store at -20 degrees; shelf life 365 days
Molecular Formula C20H28D4O5
SMILES O[C@H]1[C@H](CCC(CCCCC)=O)[C@@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)C(C1)=O
Molecular Weight 356,5
Formulation A solution in methyl acetate
Purity ≥99% deuterated forms (d1-d4)
Custom Code 2937.50
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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