Deuterated Primary Prostaglandin

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Deuterated Primary Prostaglandin Metabolite LC-MS Mixture

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Cat No: 19304

Biochemicals - Isotopically Labeled Standards

The deuterated primary prostaglandin metabolite LC-MS mixture contains deuterated forms of selected eicosanoids produced by the metabolism of arachidonic acid via the COX pathway. The mixture is supplied in an amber ampule in which the headspace has b...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

prostanoid PG LC-MS LC/MS LCMS PGE-2 PGD-2 PGF-2? PGF-2a PGF2a 11?-PGF-2? 11b-PGF-2a 15-deoxy-d12,14-PG-J2 metabolite AA deuterated deuterium gases chromatography masses spectrometry liquid isotope

Product Overview:
The deuterated primary prostaglandin metabolite LC-MS mixture contains deuterated forms of selected eicosanoids produced by the metabolism of arachidonic acid via the COX pathway. The mixture is supplied in an amber ampule in which the headspace has been purged with argon to prevent lipid oxidation. This product has been designed for direct use in LC-MS applications. This mixture is ideally suited for use as an internal standard in mass spectrometry applications. It should be noted that the mixture contains isobaric analytes. After opening, we recommend that the mixture be transferred immediately to a 1 ml glass screw cap vial, to prevent solvent evaporation, and stored at -20°C. The mixture should be discarded after multiple freeze/thaw cycles.Prostaglandin (PG) D2 (Item No. 12010), PGE2 (Item No. 14010), and PGF2α (Item No. 16010) are metabolized rapidly by the 15-hydroxy PG dehydrogenase pathway, giving 13,14-dihydro-15-keto PGD2 (Item No. 12610), 13,14-dihydro-15-keto PGE2 (Item No. 14650), and 13,14-dihydro-15-keto PGF2α (Item No. 16670), respectively. PGD2 is also metabolized to 11β-PGF2α (Item No. 16520) by 11-ketoreductase and non-enzymatically to 15-deoxy-Δ12,14-PGJ2 (Item No. 18570). This mixture contains deuterated forms of these five metabolites.

Size	1 ea
Shipping	dry ice
Formulation	A solution in ethanol (1 ?g/ml of each compound)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.