IEM 1460

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IEM 1460

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Cat No: 15623

Biochemicals - Ion Channel Modulation

IEM 1460 is an adamantine derivative that blocks both AMPA- and NMDA-type glutamate receptor (GluR) channels (IC50 = 10 μM-0.1 mM).{25561} It is selective for Ca2+-permeable GluR channels, which lack the GluR2 R subunit, and has been used to identify ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N,N,N-trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminium, bromide, hydrobromide

Correlated keywords:

176388-52-6 adamantine AMPA NMDA glutamate receptors GluR calcium Ca2+ GluR2 R neurosciences neuroprotection biochemistry signals transduction ions channels pumps blockers IEMs 1460 IEM-1460 IEM1460 opens blocker blocks permeable derivatives brains a?amino?3?hydroxy?5?methyl?4?isoxazolepropionic acid N?methyl?D?aspartate ca2+-permeable calcium-permeable .alpha.?amino?3?hydroxy?5?methyl?4?isoxazolepropionic acid alpha?amino?3?hydroxy?5?methyl?4?isoxazolepropionic acid ??amino?3?hydroxy?5?methyl?4?isoxazolepropionic acid

Product Overview:
IEM 1460 is an adamantine derivative that blocks both AMPA- and NMDA-type glutamate receptor (GluR) channels (IC50 = 10 μM-0.1 mM).{25561} It is selective for Ca2+-permeable GluR channels, which lack the GluR2 R subunit, and has been used to identify Ca2+-permeable glutamate receptors in the brain.{25561}

Size	10 mg
Shipping	dry ice
CAS Number	121034-89-7
Molecular Formula	C₁₉H₃₇N₂Br • HBr
SMILES	C[N+](C)(C)CCCCCNCC1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1.Br.[Br-]
Molecular Weight	454,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2921.30
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.