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Ro 25-6981 (maleate)

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    Ro 25-<wbr/>6981 (maleate)
  • Ro 25-<wbr/>6981 (maleate)
Cat No: 14578
Biochemicals - Ion Channel Modulation
Cayman

Ro 25-6981 (maleate) is a potent, selective activity-dependent blocker of NMDA receptors containing the NR2B subunit (IC50s = 9 nM and 52 μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A, respectively).{22852} Ro 25-6981 (maleate) d...

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This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • ?R-(4-hydroxyphenyl)-?S-methyl-4-(phenylmethyl)-1-piperidinepropanol, 2Z-butenedioate
Correlated keywords:
  • 169274-78-6 antagonists NMDA receptors NR2B subunits neuroprotections potent NR2B-selective selectives NR1C/NR2B NR1C/NR2A NR1C NR2B NR2A glutamates toxicity oxygens glucose deprivations Ro-25-6981 Ro-256981 Ro-25 6981 Ro25-6981 Ro256981 Ro25 Ros 256981 toxic deprived blockers cloned clones neuroprotectants in vitro cortical neurons activity-dependent activity dependents blocks Glu oxygen O2 N-methyl-D-aspartate
Product Overview:
Ro 25-6981 (maleate) is a potent, selective activity-dependent blocker of NMDA receptors containing the NR2B subunit (IC50s = 9 nM and 52 μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A, respectively).{22852} Ro 25-6981 (maleate) displays neuroprotectant effects in vitro, protecting cortical neurons against glutamate toxicity and combined oxygen and glucose deprivation with IC50 values of 0.4 and 0.04 μM, respectively.{22852}
Size 1 mg
Shipping dry ice
CAS Number 1312991-76-6
Molecular Formula C22H29NO2 • C4H4O4
SMILES OC1=CC=C([C@@H]([C@@H](C)CN2CCC(CC3=CC=CC=C3)CC2)O)C=C1.OC(/C=C\C(O)=O)=O
Molecular Weight 455,6
Formulation A solid
Purity ≥98%
Custom Code 2922.19
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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