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Memantine (hydrochloride)

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    Memantine (hydro<wbr/>chloride)
  • Memantine (hydro<wbr/>chloride)
Cat No: 14184
Biochemicals - Ion Channel Modulation
Cayman

Memantine is an NMDA receptor antagonist that blocks NMDA-induced currents in rat retinal ganglion cells by 90% when used at a concentration of 12 μM.{22399} It reverses inhibition of dephosphorylation of the synthetic tau phosphopeptide p17 (tau194-2...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 3,5-dimethyl-tricyclo[3.3.1.13,7]decan-1-amine, monohydrochloride
Correlated keywords:
  • 19982-08-2 Alzheimer’s diseases NMDA receptors antagonists Parkinson’s neurotoxicity glutamates neurosciences channels blocks blockers anti-epileptic anti-stroke anti-Alzheimer anti-Parkinsonian N-methyl-D-aspartate research ebixia ebixza mantine memary NSC102290 NSC-102290 SUNY7017 SUN-Y7017 rats corticol retinal ganglions cells neurons
Product Overview:
Memantine is an NMDA receptor antagonist that blocks NMDA-induced currents in rat retinal ganglion cells by 90% when used at a concentration of 12 μM.{22399} It reverses inhibition of dephosphorylation of the synthetic tau phosphopeptide p17 (tau194-207) induced by the endogenous inhibitor of protein phosphatase 2A (PP2A) I1PP2A in vitro.{41954} In vivo, memantine (2 mg/kg) restores PP2A activity, decreases GSK-3β and amyloid-β (Aβ) levels in the hippocampus, cerebral cortex, and ventricular areas, and attenuates spatial learning and memory in the AAV1-I1PP2A rat model of Alzheimer's disease. Memantine (20 mg/kg) reduces responding on the ethanol-associated lever in a cue-induced ethanol-seeking test in rats.{41955} It also decreases secretion of matrix metalloproteinase-9 (MMP-9), degradation of collagen IV, the size of cerebral ischemia-induced brain infarcts, and neuronal cell death in a mouse model of focal cerebral ischemia.{41956}
Size 10 mg
Shipping room temp.
CAS Number 41100-52-1
Molecular Formula C12H21N • HCl
SMILES N[C@]12C[C@](C[C@@](C)(C2)C3)(C)C[C@@H]3C1.Cl
Molecular Weight 215,8
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.49
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

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