MDL 29951

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MDL 29951

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Cat No: 16266

Biochemicals - Ion Channel Modulation

NMDA receptors are neuroreceptors that have binding sites for glycine or D-serine as well as L-glutamate.{27735} MDL 29951 is an antagonist of NMDA receptors with high affinity for the glycine binding site (Ki = 140 nM).{27731} It is functional both in...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-?carboxy-?4,?6-?dichloro-1H-?indole-?3-?propanoic acid

Correlated keywords:

MDL29951 allosteric inhibitor inhibit enzyme fructose 1,6-bisphosphatase FBP1 NMDA receptor antagonist glycine activation in vitro vivo N-methyl-D-aspartate biochemical agonist biochemistry signal transduction neuroscience GPR17 neurorecptor

Product Overview:
NMDA receptors are neuroreceptors that have binding sites for glycine or D-serine as well as L-glutamate.{27735} MDL 29951 is an antagonist of NMDA receptors with high affinity for the glycine binding site (Ki = 140 nM).{27731} It is functional both in vitro and in vivo.{27731} MDL 29951 blocks NMDA receptor-dependent convulsions in audiogenic seizure-susceptible DBA/2J mice.{27731} It is used to evaluate the role of the glycine site of the NMDA receptor in neurological signaling.{27734,27733} MDL 29951 is also an agonist of the G protein-coupled receptor GPR17 (EC50 values range from 7 nM to 6 µM, depending on the assay).{27732} GPR17 is thought to be involved in oligodendrocyte differentiation and myelin formation/repair.{27732}

Size	500 µg
Shipping	dry ice
CAS Number	130798-51-5
Molecular Formula	C₁₂H₉Cl₂NO₄
SMILES	ClC1=CC(Cl)=C(C(CCC(O)=O)=C(C(O)=O)N2)C2=C1
Molecular Weight	302,1
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.