Cucurbitacin I

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Cucurbitacin I

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Cat No: 14747

Biochemicals - Natural Products

Cucurbitacin I is triterpenoid compound that acts as a potent inhibitor of the STAT3/JAK signaling pathway. It specifically suppresses levels of tyrosine phosphorylated STAT3 in v-Src-transformed NIH 3T3 cells and in A549 cells (IC50 = 500 nM) resulti...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(10?)-2,16?,20,25-tetrahydroxy-9?-methyl-19-norlanosta-1,5,23E-triene-3,11,22-trione

Correlated keywords:

204376-97-6 STAT3/JAK signalings pathways triterpenoids STAT3 JAK2 JSI-124 cancers tumors growths STAT-3 STATs three signals JAK-2 JAKs JAK twos JSI124 JSI 124 tyrosine phosphorylated V-Src NIH 3T3 NIH3T3 NIH-3T3 A549 A-549 As 549 DNA bindings binds genes transcriptions cucurbitacin-I dendritic macrophages immunotherapy clonogenicity nasopharyngeal carcinoma NPCs in vitro NSCs 521777 NSC521777 NSC-521777 elatericin-B elatericins b intracellular DNA

Product Overview:
Cucurbitacin I is triterpenoid compound that acts as a potent inhibitor of the STAT3/JAK signaling pathway. It specifically suppresses levels of tyrosine phosphorylated STAT3 in v-Src-transformed NIH 3T3 cells and in A549 cells (IC50 = 500 nM) resulting in inhibition of STAT3 DNA binding and reduced STAT3-mediated gene transcription.{23520} It also suppresses JAK2 phosphorylation but does not affect Src, ERK, JNK or Akt.{23520} In nude mice, cucurbitacin I (1 mg/kg/day) suppressed growth of various tumors expressing constitutively active STAT3.{23520} It promotes the differentiation of dendritic cells and macrophages and enhances the effect of cancer immunotherapy.{23522} Cucubitacin I (1 µM for 2 hours) reduced clonogenicity of nasopharyngeal carcinoma cells in vitro and suppresses tumor growth in mice (1.3 mg/kg).{23521}

Size	1 mg
Shipping	dry ice
CAS Number	03/07/2222 00:00
Molecular Formula	C₃₀H₄₂O₇
SMILES	O=C(C1(C)C)C(O)=C[C@]2([H])C1=CC[C@]([C@@](C[C@@H](O)[C@]3([H])[C@](O)(C)C(/C=C/C(C)(O)C)=O)(C)[C@]3(C)C4)([H])[C@@]2(C)C4=O
Molecular Weight	514,7
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.