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Betulinic Acid

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    Betulinic Acid
  • Betulinic Acid
Cat No: 11686
Biochemicals - Natural Products
Cayman

Betulinic acid is a natural plant triterpenoid that is structurally related to mammalian bile acids. It is an agonist of the G protein-coupled bile acid receptor TGR5 (EC50 = 1 µM), which might be linked with its ability to alter gene expression and f...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 3?-hydroxy-lup-20(29)-en-28-oic acid
Correlated keywords:
  • natural products receptors agonists obese obesity vascular diseases atherosclerosis cancers anti-viral anti viral antiviral inflammations oxysterols plants triterpenoid bile acids G proteins coupled protein-coupled TGR5 TGR-5 TGRs 5 five genes livers HIVs HIV1 HIV-1 cancers betulic b-betulinic beta-betulinic .beta.-betulinic ?-butulinic NSCs 113090 NSC113090 NSC-113090 inhibitors inhibits oxysterols vascular NF-?B NF-.kappa.B NF-kB signaling microRNA-33 miR-33 ATP-binding cassette ABC ABCA1 cytotoxic miR33 mi R33 RNA33 NASH non-alcoholic nonalcoholic steatohepatitis NAFLD nonalcoholic fatty liver disease
Product Overview:
Betulinic acid is a natural plant triterpenoid that is structurally related to mammalian bile acids. It is an agonist of the G protein-coupled bile acid receptor TGR5 (EC50 = 1 µM), which might be linked with its ability to alter gene expression and fatty liver development in cells and mice given ethanol.{24274,24272,24270} Betulinic acid also reduces NF-κB signaling and expression of microRNA-33 in LPS-treated macrophages, increasing levels of the ATP-binding cassette (ABC) cholesterol transporter ABCA1.{24273} It also inhibits replication of HIV-1 (IC50 = 1.4 µM) and has cytotoxic effects against cancer cells.{24270,22046}
Size 50 mg
Shipping wet ice
CAS Number 472-15-1
Molecular Formula C30H48O3
SMILES CC([C@@H]1CC[C@]2(C(O)=O)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3([H])[C@]21[H])=C
Molecular Weight 456,7
Formulation A solid
Purity ≥97%
Custom Code 2918.99
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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