Nomilin

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Nomilin

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Cat No: 20836

Biochemicals - Natural Products

Nomilin is a limonoid triterpenoid that has been found in grapefruit seeds and has diverse biological activities, including antiviral, antiproliferative, and anti-obesity properties.{42298} It dose-dependently reduces HIV-1 replication in infected hum...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(1S,3aS,4aR,4bR,6aR,11S,11aR,11bR,13aS)-11-(acetyloxy)-1-(3-furanyl)decahydro-4b,7,7,11a,13a-pentamethyl-oxireno[4,4a]-2-benzopyrano[6,5-g][2]benzoxepin-3,5,9(3aH,4bH,6H)-trione

Correlated keywords:

NSC297134 anti-viral proliferative antiobesity HIV1 MMP2 MMP9 TGR-5 HEK-293

Product Overview:
Nomilin is a limonoid triterpenoid that has been found in grapefruit seeds and has diverse biological activities, including antiviral, antiproliferative, and anti-obesity properties.{42298} It dose-dependently reduces HIV-1 replication in infected human peripheral blood mononuclear cells (PBMCs; EC50 = 52.2 μM) and reduces human umbilical vein endothelial cell (HUVEC) proliferation, invasion, tube formation, and matrix metalloproteinase-2 (MMP-2) and MMP-9 activity without reducing cell viability when used at concentrations ranging from 5 to 25 µg/ml.{42299,42300} Nomilin (100 μM) increases luciferase activity 5.5-fold when the G protein-coupled receptor TGR5 is expressed in HEK293 cells with a TGR5-dependent reporter gene.{42301} It increases GST activity in the small intestinal mucosa, liver, and forestomach of mice by 4.17-, 3.44-, and 1.16-fold, respectively, when administered at a dose of 10 mg/kg.{42298} Nomilin (0.2% w/w, p.o.) completely prevents weight gain and reduces serum glucose and insulin levels by 30 and 89.8%, respectively, in mice fed a high-fat diet.{42301} It also increases the white blood cell count and the specific antibody titer in blood by approximately 10-fold in mice in response to sheep red blood cells when administered at a dose of 10 μmol/kg.{42302}

Size	10 mg
Shipping	dry ice
CAS Number	1063-77-0
Molecular Formula	C₂₈H₃₄O₉
SMILES	CC([C@@](C1)([H])[C@@]([C@@H](OC(C)=O)C2)(C)[C@@]([C@@]3(C)C1=O)([H])CC[C@]4(C)[C@]3(O5)[C@H]5C(O[C@H]4C6=COC=C6)=O)(C)OC2=O
Molecular Weight	514,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.