Cryptotanshinone

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Cryptotanshinone

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Cat No: 16987

Biochemicals - Natural Products

Cryptotanshinone is a natural quinoid diterpene first isolated from Salvia miltiorrhiza roots, which are used in traditional Chinese medicine for a variety of conditions.{28060} Cryptotanshinone, at 10-20 µM, stimulates AMP-activated protein kinase in...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(1R)-1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-phenanthro[1,2-b]furan-10,11-dione

Correlated keywords:

4733-35-1 biochemical natural products anti-cancer inhibitors inhbit intracellular signaling signal transduction inflammation vascular disease alzheimer’s research diabetes obesity antioxidant quinoid diterpene diverse action AMPK C2C12 myotube p38MAPK DU145 cell SHP2 phosphorylation STAT3 MC-3 cell proliferation apoptosis angiogenesis, tanshinone c, salvia miltiorrhiza

Product Overview:
Cryptotanshinone is a natural quinoid diterpene first isolated from Salvia miltiorrhiza roots, which are used in traditional Chinese medicine for a variety of conditions.{28060} Cryptotanshinone, at 10-20 µM, stimulates AMP-activated protein kinase in C2C12 myotubes and activates p38 MAPK in DU145 cells.{28058,28059} It inhibits the protein tyrosine phosphatase SHP2 in vitro (IC50 = 22.5 µM) and, at 4-8 µM, blocks phosphorylation of STAT3 in MC-3 cells.{28057,28056} Cryptotanshinone has a variety of anti-cancer actions, including inhibition of cell proliferation, induction of apoptosis, and reduction in angiogenesis.{28060,28056,28055} However, it is poorly absorbed and has low bioavailability in vivo.{28055}

Size	5 mg
Shipping	dry ice
CAS Number	35825-57-1
Molecular Formula	C₁₉H₂₀O₃
SMILES	O=C(C1=O)C2=C(OC[C@@H]2C)C3=C1C(CCCC4(C)C)=C4C=C3
Molecular Weight	296,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2918.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.