(+)-Aphidicolin

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(+)-Aphidicolin

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Cat No: 14007

Biochemicals - Natural Products

(+)-Aphidicolin is a natural tetracyclic diterpene first isolated from the fungus C. aphidicola and shown to have antiviral activity against herpes simplex.{22496} In eukaryotic cells, it is a cell-permeable, reversible inhibitor of DNA replication, s...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3R,4R,4aR,6aS,8R,9R,11aS,11bS)-tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol

Correlated keywords:

53334-90-0 inhibitors inhibits inhibitions natural cells cycles NSC-234714 ICI-69653 NSC234714 ICI69653 products antivirals anti-virals anti virals tetracyclics diterpenes Cephalosporium C. aphidicola herpes permeables DNA deoxyribonucleic acids G1 phases S polymerases cell-permeables antibiotics antimotitical eukarotics nuclear replications apoptosis inducer induction HeLa genes amplifications BRN4689958 BRN 4689958 BRN-4689958 +-Aphidicolin +Aphidicolin +

Product Overview:
(+)-Aphidicolin is a natural tetracyclic diterpene first isolated from the fungus C. aphidicola and shown to have antiviral activity against herpes simplex.{22496} In eukaryotic cells, it is a cell-permeable, reversible inhibitor of DNA replication, specifically blocking the activity of DNA polymerases α, δ, and ε when used at low micromolar levels.{22501,22499,22497} Aphidicolin can be used, at 3 μM, to arrest cells in G1/S phase or to increase gene amplification frequency.{22498,22502}

Size	1 mg
Shipping	dry ice
CAS Number	38966-21-1
Molecular Formula	C₂₀H₃₄O₄
SMILES	O[C@]1(CO)CC[C@]23[C@@](C[C@@H]1C3)([H])CC[C@@]4([H])[C@@](CO)(C)[C@H](O)CC[C@@]42C
Molecular Weight	338,5
Formulation	A solid
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.