Acyclovir

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Acyclovir

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Cat No: 14160

Biochemicals - Small Molecule Inhibitors

Acyclovir is a guanosine analog that has antiviral activity in vitro against the herpes simplex viruses, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and human herpes virus 6 (ID50s = 0.1-63.1 μM).{22178} It diffuses freely into cells ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one

Correlated keywords:

aciclovir guanosines analogs anti-virals anti virals antivirals herpes simplex viruses HSV varicella zoster VZV Epstein-Barr EBV cytomegalovirus CMV humans herpes 6 HHV-6 nucleoside viral DNA replications HHV6 HHV cells acyclo-guanosine monophosphates polymerases acicloftal acivir acyclo V acycloguanosine avirase bioVir I II cargosil gerpevir herpevir lovir novirus poviral rouz-aciclovir vicclox vipral virax virless virorax virovir wellcome 248U zirax zovirax zyclir BW248U BW-248U NSC645011 NSC-645011 in vitro necleosides acyclics side chains diffuses diffusion free cells thyamines kinases deoxyribonucleic acids phosphorylateds chains terminations inhibitions inhibitors inhibits

Product Overview:
Acyclovir is a guanosine analog that has antiviral activity in vitro against the herpes simplex viruses, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and human herpes virus 6 (ID50s = 0.1-63.1 μM).{22178} It diffuses freely into cells and is selectively converted into acyclo-guanosine monophosphate by a virus-specific thymidine kinase. During DNA replication, the phosphorylated form of acyclovir is preferentially incorporated into viral DNA, resulting in premature chain termination and inhibition of further DNA polymerase activity.{22179} Acyclovir (5 mg/kg) reduces viral titers in mice infected with the herpes simplex virus-1 (HSV-1) strain SC16.{48054}

Size	25 mg
Shipping	dry ice
CAS Number	59277-89-3
Molecular Formula	C₈H₁₁N₅O₃
SMILES	O=C1C2=C(N(COCCO)C=N2)N=C(N)N1
Molecular Weight	225,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.