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Cidofovir

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    Cidofovir
  • Cidofovir
Cat No: 13113
Biochemicals - Anti-Infection
Cayman

Cidofovir is an acyclic nucleoside phosphonate that is active against herpesvirus (including cytomegalovirus (CMV)), polyomavirus, papillomavirus, adenovirus, and poxvirus infections. In vitro, cidofovir is converted to cidofovir diphosphate which inc...

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This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-phosphonic acid
Correlated keywords:
  • anti-viral MRC5 AD169 cow-pox Vistide Cidovir GS0504
Product Overview:
Cidofovir is an acyclic nucleoside phosphonate that is active against herpesvirus (including cytomegalovirus (CMV)), polyomavirus, papillomavirus, adenovirus, and poxvirus infections. In vitro, cidofovir is converted to cidofovir diphosphate which incorporates into viral DNA, selectively inhibiting CMV replication and CMV DNA synthesis with IC50 values of 0.1 μM.{22167} Cidofovir has significantly long-lasting antiviral action because of the long half-life of its metabolites whose cellular uptake is slow due to the presence of the negatively charged phosphonate group.{22169} The antiviral efficacy of cidofovir has been demonstrated in numerous experimental animal model infections that mirror all major DNA virus infections in humans.{22168} It has also demonstrated remarkable activity as an antitumor agent in a variety of animal models of tumor growth.{22168}
Size 25 mg
Shipping dry ice
CAS Number 113852-37-2
Molecular Formula C8H14N3O6P
SMILES NC(C=CN1C[C@H](OCP(O)(O)=O)CO)=NC1=O
Molecular Weight 279,2
Formulation A crystalline solid
Purity ≥95%
Custom Code 2922.19
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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