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BRD4 bromodomain 1 (human, recombinant; GST-tagged)

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    BRD4 bromodomain 1 (human, recombinant; GST-<wbr/>tagged)
  • BRD4 bromodomain 1 (human, recombinant; GST-<wbr/>tagged)
Cat No: 11068
Proteins - More Proteins
Cayman
€376.00
Price is excluding VAT and does not include packaging neither shipping

Key FeaturesCayman’s BRD4 bromodomain 1 TR-FRET Assay Kit (Item No. 600520) was developed using BRD4 bromodomain 1 (human recombinant; GST-tagged) protein.Bulk sizes available upon request The acetylation of histone lysine residues plays a crucial rol...

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: 100 µg

This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Pharma only in Europe
Correlated keywords:
  • BET proteins BRD2 BRD3 BRD4 I-BET genes expression histones chromatin acetylation IBET BRD BRD-2 BRD-3 BRD-4 bromodomains epigenetics lysine nucleosomes cellular inflammatory mitosis viral hosts
Product Overview:
Key FeaturesCayman’s BRD4 bromodomain 1 TR-FRET Assay Kit (Item No. 600520) was developed using BRD4 bromodomain 1 (human recombinant; GST-tagged) protein.Bulk sizes available upon request The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain.{19952} These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT.{19953} The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions.{19559,19558,19930} The isolated individual or tandem bromodomains of BRD2 and BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters.{19959,19960,19961,19962,19558} Small molecule inhibitors of these interactions hold promise as useful therapeutics for human disease.{19044,19929,19950}
Size 100 µg
Shipping dry ice
Stability Store at -80 degrees; shelf life 730 days
Formulation 50 mM Tris, pH 7.5, with 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol
Purity ≥95% estimated by SDS-PAGE
Custom Code 3504.00
UNSPSC code 12352204

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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