BRD7 bromodomain (human, recombi

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BRD7 bromodomain (human, recombinant)

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Cat No: 14491

Proteins - More Proteins

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain.{19952} These domains function in linking pr...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

genes regulations epigenetics chromatin reseach cancers recombinants proteins histones acetylation bromodomain lysine residues domains transcriptions nucleosomes regulating regulates targets promoters subunits polybromo-associated BRG1 PBAF components SW1/SNF remodeling complexes tumors supressors cofactors p53 breasts tumorigenicity BRCA1 dependents estrogen receptors ? expressions nasopharyngeal carcinomas colorectal transcriptional silencing PRMT5 PRC2 regions complex 2 switch sucrose breasts cancers type 1 proteins arginine methyltransferases 5 polycomb repressive non-fermentable

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The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain.{19952} These domains function in linking protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters.{20313} BRD7 is a subunit of the polybromo-associated BRG1-associated factor (PBAF)-specific component of the switch/sucrose non-fermentable chromatin-remodeling complex.{23106} It has a tumor suppressor role by acting as a cofactor for p53 and regulating breast cancer tumorigenicity.{23107,23108} Cells lacking BRD7 have reduced breast cancer type 1-dependent estrogen receptor α expression.{23108} Down-regulation of BRD7 has been demonstrated in nasopharyngeal carcinoma cell lines and in colorectal cancer.{23109,23107} BRD7 is also involved in transcriptional gene silencing through binding to protein arginine methyltransferase 5 and polycomb repressive complex 2. This protein product contains the bromodomain region of BRD7.

Size	100 µg
Shipping	dry ice
Formulation	50 mM Tris, pH 8.0, with 150 mM sodium chloride and 20% glycerol
Purity	≥70% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.