L3MBTL1 MBT domains (human recom

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L3MBTL1 MBT domains (human recombinant; GST-tagged)

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Cat No: 14775

Proteins - More Proteins

Key Features Cayman’s L3MBTL1 MBT Domains TR-FRET Assay Kit (Item No. 601030) was developed using L3MBTL1 MBT domains (human recombinant; GST-tagged) protein.Bulk sizes available upon request "The malignant brain tumor (MBT) domain is structurally re...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

NP_056293 NP056293 L3M-BTL1 L3MBTL-1 H3K4-me1 H4K20-me2

Product Overview:
Key Features Cayman’s L3MBTL1 MBT Domains TR-FRET Assay Kit (Item No. 601030) was developed using L3MBTL1 MBT domains (human recombinant; GST-tagged) protein.Bulk sizes available upon request "The malignant brain tumor (MBT) domain is structurally related to chromatin binding domains, such as chromodomains, tudor domains, and PWWP-domains.{24018,22297} MBT domain-containing proteins have a variable number of MBT repeats. The MBT domains recognize methylated lysines on histone tails with varying degree of specificity for the various methyl marks.{24018} L3MBTL1, a human homolog of the Drosophila lethal(3)MBT protein, is a member of the polycomb group (PcG) of proteins that functions as a transcriptional repressor.{24020} L3MBTL1 contains three MBT repeat domains which collectively bind to either histone H3 or H4.{24018,24022} The second and third MBT domains were found to bind preferentially to mono- and dimethylated lysines of histone H3 at lysine 4 (H3K4me1) and histone H4 at lysine 20 (H4K20me2).{24022,18035} Recognition of methyl-lysine marks by MBT domains leads to chromatin compaction and a repressed transcriptional state.{24022,24021} Further, L3MBTL1 has a tumor suppressor function and is thought to play a role in maintaining genomic stability and DNA replication.{24019,24017} This protein product contains the MBT repeat region of L3MBTL1."

Size	100 µg
Shipping	dry ice
Formulation	50 mM Tris, pH 8.0, with 150 mM sodium chloride and 20% glycerol
Purity	≥90% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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