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ATAD2 bromodomain (human recombinant)

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    ATAD2 bromodomain (human recombinant)
  • ATAD2 bromodomain (human recombinant)
Cat No: 14490
Proteins - More Proteins
Cayman

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain.{19952} These domains function in linking pr...

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: 100 µg

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Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
  • genes regulations epigenetics chromatins researchers ATPase containing contains H3K14ac cancers proteins recombinant histones acetylations bromodomains AAA nuclear coregulator cancer-associated proteins lysines residues genes regulates regulating transcriptions acetylated small complexes readers marks markers targets promoters AAA+ ATPase-containing adenosines triphosphates enzyme-containing estrogens androgens receptors tumors E2F MYC signals signaling pathways binds bindings oncogenes transcriptional activity activities modifying 14 H3 cells cycles progressions
Product Overview:
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain.{19952} These domains function in linking protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as "readers" of histone acetylation marks regulating the transcription of target promoters.{20313} ATAD2 is an AAA+ ATPase-containing nuclear transcriptional coactivator for the estrogen and androgen receptors.{22880,22881} ATAD2 is highly expressed in several types of tumors and has been proposed to link the E2F and MYC signaling pathways. Binding to the MYC oncogene stimulates its transcriptional activity, leading to the development of aggressive cancers with poor prognosis.{22878} ATAD2 is important for the assembly of chromatin modifying complexes and its bromodomain associates with acetylated lysine 14 on histone H3 to regulate the genes required for cell cycle progression.{22880,22879}
Size 100 µg
Shipping dry ice
Formulation 50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol
Purity ≥90%
Custom Code 3504.00
UNSPSC code 12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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