Brazilin

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Brazilin

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Cat No: 22456

Biochemicals - Natural Products

Brazilin is an isoflavonoid originally isolated from C. sappan that has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties.{41009} Brazilin inhibits Aβ (1-42) fibrillogenesis (IC50 = ...

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About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

7,11bR-dihydro-benz[b]indeno[1,2-d]pyran-3,6aS,9,10(6H)-tetrol

Correlated keywords:

22562-62-5 brazilwood Braziletto NSC56652 Superbresiline Limawood Extract Receptor antiinflammatory anti-bacterial oxidant brasilin

Product Overview:
Brazilin is an isoflavonoid originally isolated from C. sappan that has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties.{41009} Brazilin inhibits Aβ (1-42) fibrillogenesis (IC50 = 1.5 µM) more potently than (-)-epigallocatechin gallate (Item No. 70935), cucurmin (Item No. 81025), and resveratrol (Item Nos. 10004235
70675).{41007} It also prevents remodeling of mature Aβ (1-42) fibrils. Brazilin inhibits the production of cytokines, including PGE2 (Item No. 14010) and TNF-α (IC50s = 12.6 and 87.2 µM).{41011} It is effective against Gram-positive and Gram-negative bacteria with MICs ranging from 31.3 to 250 µg/ml.{41010} In addition, brazilin inhibits osteoclast differentiation mediated by RANKL and is protective against LPS-induced osteoporosis in mice at a dose of 100 mg/kg.{41008}

Size	1 mg
Shipping	dry ice
CAS Number	474-07-7
Molecular Formula	C₁₆H₁₄O₅
SMILES	OC(C=C1)=CC2=C1[C@](C(C=C(O)C(O)=C3)=C3C4)([H])[C@]4(O)CO2
Molecular Weight	286,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2907.29
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.