Isosakuranetin

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Isosakuranetin

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Cat No: 25198

Isosakuranetin is a flavanone that has been found in Citrus species and has diverse biological activities.{39812,39817,39813,39814,39815,39816,39818} It inhibits calcium uptake induced by pregnenolone sulfate (PregS; Item No. 21004) in HEK293 cells ex...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2S)-2,3-dihydro-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

Correlated keywords:

24557-94-6 Naringenin4'methylether methylether HEK-293 TRPM-3 TRPM-1 8 TRPV-1 MMP1 ERK-1/2 PC-12 anti-bacterial Mycobacterium Cryptococcus Trypanosoma UVB Citrifoliol Naringenin-4'-methyl ether Ponciretin

Product Overview:
Isosakuranetin is a flavanone that has been found in Citrus species and has diverse biological activities.{39812,39817,39813,39814,39815,39816,39818} It inhibits calcium uptake induced by pregnenolone sulfate (PregS; Item No. 21004) in HEK293 cells expressing mouse transient receptor potential melastatin 3 (TRPM3; IC50 = 50 nM).{39812} Isosakuranetin is selective for TRPM3 over TRPM1, TRPM8, and TRP vanilloid-related 1 (TRPV1) when used at a concentration of 10 μM. In vivo, isosakuranetin (2 mg/kg) increases latency to first pain-related response in mice in a hot plate test and reduces the number and duration of PregS-induced nocifensive responses, such as paw licking, shaking, or lifting, in mice. It also reduces systolic blood pressure in spontaneously hypertensive rats when administered at a dose of 10 mg/kg.{39817} Isosakuranetin (20 µM) inhibits UV-B-induced matrix metalloproteinase-1 (MMP-1) expression by 90% in HaCaT human keratinocyte cells, as well as phosphorylation of ERK1/2 when used at a concentration of 50 µM.{39813} It blocks hydrogen peroxide-induced increases in reactive oxygen species (ROS), intracellular calcium concentration, caspase-3 activity, and JNK phosphorylation, as well as decreases in catalase activity, in PC12 cells when used at a concentration of 0.8 µM.{39814} Isosakuranetin also has antibacterial and trypanocidal activity against M. tuberculosis, C. neoformans, and T. cruzi.{39815,39816,39818}

Size	1 mg
Shipping	dry ice
CAS Number	480-43-3
Molecular Formula	C₁₆H₁₄O₅
SMILES	O=C1C2=C(C=C(O)C=C2O)O[C@H](C3=CC=C(OC)C=C3)C1
Molecular Weight	286,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2907.29
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.