Fisetin

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Fisetin

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Cat No: 15246

Biochemicals - Lipids

Fisetin is a flavonoid that has been found in various fruits and vegetables and has diverse biological activities.{61545,61546,61547,61548} It scavenges radicals in a Trolox equivalent antioxidant capacity (TEAC) assay and inhibits oxidative burst ind...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one

Correlated keywords:

biochemical natural product antioxidant inhibitor cancer oxidative injury intracellular signaling signal transduction flavonoid inflammation inhibit flavonol anti-inflammatory activator sirtuin 1 SIRT1 spleen tyrosine kinase SYK suppressor CD36 gene expression 3,3',4',7-tetrahydroxyflavone 5-Desoxyquercetin Bois Bleu de Honqrie C.I. 75620 C.I.75620 CI Natural Brown 1 Cotinin Fiestin Fietin Fisetholz Fisitin Fustel Fustet Junger Fustik LDN 0058389 LDN0058389 Superfustel K Ungarisches Gelbholz Ventin Sumach Viset Young Fustic Crystals Zante

Product Overview:
Fisetin is a flavonoid that has been found in various fruits and vegetables and has diverse biological activities.{61545,61546,61547,61548} It scavenges radicals in a Trolox equivalent antioxidant capacity (TEAC) assay and inhibits oxidative burst induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP; Item No. 21495) in isolated human polymorphonuclear neutrophils (PMNs) when used at a concentration of 10 µM.{61545,61547} Fisetin (10-60 µM) induces cell cycle arrest at the G1 phase and apoptosis in, as well as inhibits the proliferation of, LNCaP prostate cancer cells.{61546} It inhibits LPS-induced production of nitrite, prostaglandin E2 (PGE2; Item No. 14010), and NF-κB activation in RAW 264.7 cells.{61547} Fisetin (1 mg/animal) reduces tumor growth in a CWR22Rυ1 prostate cancer mouse xenograft model.{61548}

Size	100 mg
Shipping	dry ice
CAS Number	528-48-3
Molecular Formula	C₁₅H₁₀O₆
SMILES	O=C1C2=C(C=C(O)C=C2)OC(C3=CC=C(O)C(O)=C3)=C1O
Molecular Weight	286,2
Formulation	A crystalline solid
Purity	≥90%
Custom Code	2932.99
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.