Histone H3S10Ph Monoclonal Antib

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Histone H3S10Ph Monoclonal Antibody

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Cat No: 20720

Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that ex...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

H 3 S10Ph pS10 pSer10 Ser 10 posttranslational HP 1? alpha lys9

Product Overview:
Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Phosphorylation of histone H3 at serine 10 (H3S10Ph) is correlated with chromatin condensation during mitosis and with transcriptional activation of genes during interphase.{47274,32235} H3S10Ph does not inhibit binding of the ADD domain of the chromatin-remodeling protein ATRX to histone H3 N-terminal peptides due to its positioning away from the core peptide binding sequence but does decrease binding of the HP1α chromodomain (CD) when the histone H3 peptide is also trimethylated at lysine 9.{47275} Low median levels of H3S10Ph in tumor tissue isolated from patients with oral squamous cell carcinoma (OSCC) are associated with cervical lymph node metastasis.{54491} Cayman's Histone H3S10Ph Monoclonal Antibody can be used for ELISA, immunocytochemistry (ICC), multiplex-based assay, and Western blot (WB) applications.

Size	100 µg
Shipping	dry ice
Host	Rabbit
Antigen	Peptide corresponding to H3S10Ph
Clone	RM163
Isotype	IgG
Application(s)	ELISA, ICC, multiplex-based assay, WB
Formulation	100 µg of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.