Histone H3K4Me2 Polyclonal Antib

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Histone H3K4Me2 Polyclonal Antibody

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Cat No: 18198

Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that ex...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

core histone H2A H2B H3 H4 H-2A H-2B H-3 H-4 H3 K4 H3K-4 SET SET1 1 domain MLL SET 1 MLL MLL2 MLL3 MLL4 KMT2 KMT-2 methylation dimethylation trimethylation post-translational postranslational modification nucleosome SMYD H3K4Me 2

Product Overview:
Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Dimethylation of H3K4 is catalyzed by SET domain-containing histone methyltransferases, including SET1, MLL1, -2, -3, and -4, and SMYD3, and dysregulation of these methyltransferases is associated with various diseases, including breast and prostate cancer and Alzheimer's disease in humans. H3K4Me2 is highly enriched in the promoter region of transcriptionally active genes, as well as primed, inactive genes that are targeted for future transcription.{47296} Cayman's Histone H3K4Me2 Polyclonal Antibody can be used for ELISA and Western blot applications. It detects H3K4Me2 at ~16 kDa from human samples.

Size	1 ea
Shipping	dry ice
Host	Rabbit
Antigen	Synthetic peptide from the N-terminal region of human Histone H3 (dimethyl K4) conjugated to KLH
Application(s)	ELISA and WB
Formulation	500 µl of peptide affinity-purified antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.