Histone H3K4Me2 Monoclonal Antib

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Histone H3K4Me2 Monoclonal Antibody

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Cat No: 14137

Histones are nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. The basic structure is a 146 bp strand of DNA wrapped around a histone octamer containing pairs of the four core histones (H2A, H2B...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

H3K4-Me2 H3K4Me-2

Product Overview:
Histones are nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. The basic structure is a 146 bp strand of DNA wrapped around a histone octamer containing pairs of the four core histones (H2A, H2B, H3, and H4). Histones are subjected to numerous post-translational modifications including methylation. Histone lysine methylation is an important post-translational modification linked to diverse biological pathways including gene transcription, heterochromatin maintenance, and double-stranded DNA break repair.{20250} Most lysine methylation events are carried out by a SET domain-containing HMTase, and methylation at lysine 4 of histone 3 (H3K4) is an evolutionarily conserved modification associated with transcriptionally active chromatin.{19551,20252} The SET1/MLL (KMT2) family of methyltransferases is the principal enzyme family responsible for H3K4 methylations.{19551,19556} The WDR5/RbBP5/Ash21/DPY-30 subcomplex is required for the H3K4 dimethylation activity of the MLL1 core complex.{20268} Cayman's Histone H3K4Me2 Monoclonal Antibody detects dimethylated histone H3 and does not detect unmodified histone H3.

Size	100 µg
Shipping	dry ice
Host	Mouse
Antigen	Synthetic peptide from the N terminal region of human histone H3K4Me2 conjugated to KLH
Isotype	IgG2a?
Application(s)	FC, WB
Formulation	100 µg of protein G-purified antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.