6-thio-2?-Deoxyguanosine

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Cat No: 19154

Biochemicals - More Biochemicals

6-thio-2′-Deoxyguanosine (6-thio-dG) is a nucleoside analog that is incorporated into de novo-synthesized telomeres by telomerase.{31123,31124} This induces telomerase dysfunction resulting in telomeric DNA damage and rapid cell death.{31123} This pro...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2'-deoxy-6-thio-guanosine

Correlated keywords:

1688-22-8 2239-63-6 30241-92-0 1630035-44-7 6-deoxythioguanosine 6thio-dG telomerase dysfunction cell death nucleoside analog NSC71261 TGdR 6thiodG inducer A-549 PD1 PDL1 MC38 Calu3

Product Overview:
6-thio-2′-Deoxyguanosine (6-thio-dG) is a nucleoside analog that is incorporated into de novo-synthesized telomeres by telomerase.{31123,31124} This induces telomerase dysfunction resulting in telomeric DNA damage and rapid cell death.{31123} This process occurs in cells expressing telomerase but not in telomerase-negative cells.{31123} DNA containing 6-thio-dG inhibits the function of RNase H, preventing the cleavage of DNA-RNA heteroduplexes.{31122} In mouse xenograft studies using A549 lung cancer cells, 6-thio-dG causes a decrease in tumor growth rate associated with telomere dysfunction.{31123}

Size	1 mg
Shipping	dry ice
CAS Number	789-61-7
Molecular Formula	C₁₀H₁₃N₅O₃S
SMILES	O[C@H]1C[C@H](N2C=NC3=C2N=C(N)NC3=S)O[C@@H]1CO
Molecular Weight	283,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2930.90
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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