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6-Thioguanine

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    6-<wbr/>Thioguanine
  • 6-<wbr/>Thioguanine
Cat No: 15774
Biochemicals - More Biochemicals
Cayman

6-Thioguanine (6-TG) is a thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity.{25754,25756} Upon incorporation into DNA, 6-TG has...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 2-amino-1,9-dihydro-6H-purine-6-thione
Correlated keywords:
  • 611-?67-?6 1125-?65-?1 1832-?72-?0 5632-?51-?9 153981-?50-?1 158476-?00-?7 thiopurines antimetabolites anti metabolites anti-metabolites chemotherapy purines analogs DNA damages double strands breaks cancers cytotoxicity thio purines cytosines methylation methyltransferases leukemia tumors BRCA2 BRCA-2 BRCAs 2 two mutated epigenetics thioguanine thioguanine six 6 lanvis S6G tabloid TGs thio-guanine NSCs 752 76504 NSC752 NSC76504 NSC-752 NSC-76504 genes regulations chemotherapeutics BRCA2-mutated repairs 2-Amino-6-mercaptopurine Tioguanin Tioguanine
Product Overview:
6-Thioguanine (6-TG) is a thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity.{25754,25756} Upon incorporation into DNA, 6-TG has been shown to disrupt cytosine methylation by DNA methyltransferases, interfering with the epigenetic pathway of gene regulation.{25757,25758} This compound has been used as a chemotherapeutic for acute leukemia and other types of cancer, including BRCA2-mutated tumors.{25755}
Size 250 mg
Shipping dry ice
CAS Number 154-42-7
Molecular Formula C5H5N5S
SMILES NC1=NC(S)=C2C(NC=N2)=N1
Molecular Weight 167,2
Formulation A crystalline solid
Purity ≥95%
Custom Code 2930.90
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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