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8-Nitroguanine

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    8-Nitroguanine
  • 8-Nitroguanine
Cat No: 89295
Biochemicals - Small Molecule Inhibitors
Cayman

8-Nitroguanine is a nitrative guanine derivative formed by oxidative damage to the guanine base in DNA by reactive nitrogen species (RNS) during inflammation and in vitro by reaction of DNA with peroxynitrite and other RNS reagents.{40813,40814,40815}...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 2-amino-1,9-dihydro-8-nitro-6H-purin-6-one
Correlated keywords:
  • 8NO2Gua histiocytoma 8Nitroguanine 8NO2 8nitrog 8nitrodg 8-NO2-G 8-nitroG 8-nitroGua 8-nitrodG GC AT antiG 8-NO2-Gua
Product Overview:
8-Nitroguanine is a nitrative guanine derivative formed by oxidative damage to the guanine base in DNA by reactive nitrogen species (RNS) during inflammation and in vitro by reaction of DNA with peroxynitrite and other RNS reagents.{40813,40814,40815} It is mutagenic and induces G:C to T:A transversion in DNA. Incorporation of 8-nitroguanine as an 8-nitroG:anti-G base pair into a primer template stalls human DNA polymerase β and induces a 2:1 preference for deoxyadenosine (dA) insertion over deoxycytosine (dC).{40815} 8-Nitroguanine levels are increased in the lung tissue of mice with conditional expression of mutant K-Ras(G12V) that developed lung adenocarcinoma and in the lung tissue and peripheral lymphocyte DNA of cigarette smoke-exposed rats.{40816,40817} It is also increased in the lung tissue of influenza- or Sendai virus-infected mice and the colon epithelial cells of mice in an inflammatory bowel disease (IBD) model.{40818,40819}
Size 1 mg
Shipping dry ice
CAS Number 168701-80-2
Molecular Formula C5H4N6O3
SMILES O=C1C2=C(N=C([N+]([O-])=O)N2)N=C(N)N1
Molecular Weight 196,1
Formulation A solid
Purity ≥95%
Custom Code 2924.19
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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