(R)-Pramipexole (hydrochloride)

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Cat No: 18234

Biochemicals - Receptor Pharmacology

Pramipexole (Item No. 11981) is an agonist of dopamine receptors that has applications in Parkinson’s disease and other disorders.{21783,21784,21785,21786} Pramipexole is usually available as a mixture of enantiomers, with the majority of the dopamine ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazolediamine, dihydrochloride

Correlated keywords:

104632-28-2 biochemical inhibitor Parkinson’s research signal transduction apoptosis intracellular signaling receptor biochemistry neuroscience antioxidant inhibit KNS760704 SND919CL2X anti-apoptotic enantiomer negative control mitochondria cytoprotective amyotrophic lateral sclerosis ALS antiapoptotic anti-oxidant

Product Overview:
Pramipexole (Item No. 11981) is an agonist of dopamine receptors that has applications in Parkinson’s disease and other disorders.{21783,21784,21785,21786} Pramipexole is usually available as a mixture of enantiomers, with the majority of the dopamine receptor-dependent activity resulting from the (S) form.{29401} (R)-Pramipexole is an enantiomer of pramipexole that is ~100-fold less active than the (S) form as a dopamine receptor agonist.{29401,29399} For this reason, it can be used as a negative control for the (S) form in the study of dopamine receptors. Both isoforms are antioxidants that target mitochondria to prevent apoptosis.{29401,29402,29398,29403} This cytoprotective effect of (R)-pramipexole, without dopaminergic side effects, suggests utility in amyotrophic lateral sclerosis.{29401,29400}

Size	5 mg
Shipping	dry ice
CAS Number	104632-27-1
Molecular Formula	C₁₀H₁₇N₃S • 2HCl
SMILES	CCCN[C@@H]1CCC(N=C(N)S2)=C2C1.Cl.Cl
Molecular Weight	284,2
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2930.90
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.