Rotigotine

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Rotigotine

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Cat No: 20246

Biochemicals - Receptor Pharmacology

Rotigotine is a non-selective dopamine receptor agonist with pEC50 values of 9.6, 10.4, 8.2, 7.7, and 7.7 for D1, D2, D3, D4, and D5, respectively.{32322} It demonstrates a high-affinity for D1, D2, and D3 with lesser affinity for D4 and D5 receptor ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(6S)-5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol

Correlated keywords:

dopamine receptor apomorphine pergolide pramipexole ropinirole SPM962 neupro N0427 N0923 neupro (S)-(-)-rotigotine N-0427 antiparkinsonian

Product Overview:
Rotigotine is a non-selective dopamine receptor agonist with pEC50 values of 9.6, 10.4, 8.2, 7.7, and 7.7 for D1, D2, D3, D4, and D5, respectively.{32322} It demonstrates a high-affinity for D1, D2, and D3 with lesser affinity for D4 and D5 receptor subtypes.{32322} This binding profile is similar to that of apomorphine (Item No. 16094) and pergolide but differentiated from that of pramipexole (Item No. 11981) and ropinirole, which have a more narrow profile of receptor specificity.{32322} Each of these agonists demonstrates anti-Parkinsonian effects in animal and clinical models through their ability to directly activate dopamine receptors.{32322}

Size	1 mg
Shipping	dry ice
CAS Number	99755-59-6
Molecular Formula	C₁₉H₂₅NOS
SMILES	OC1=C(CC[C@H](N(CCC2=CC=CS2)CCC)C3)C3=CC=C1
Molecular Weight	315,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2907.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.