(±)-SKF 81297 (hydrobromide)

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Cat No: 15067

Biochemicals - Receptor Pharmacology

(±)-SKF 81297 is a selective agonist of the dopamine D1-like receptor (Ki = 1.9 nM).{24103} It demonstrates comparatively lower binding affinity for the dopamine D2, dopamine D3, serotonin 5-HT2A, and adrenergic α2 receptors (Kis = 1,272, >10,000, 955...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

6-?chloro-?2,?3,?4,?5-?tetrahydro-?1-?phenyl-1H-?3-?benzazepine-?7,?8-?diol, monohydrobromide

Correlated keywords:

71636-61-8 agonists dopamines D1-like D1 likes receptors rewards related reward-related incentives learning neurosciences SKFs 81297 SKF-81297 SKF81297 signaling learn signals selectives binding affinity serotonin-2A serotonin 2A 2 A D 1 2 3 D2 D3 adrenergic ?2 ? 2 alpha2 .alpha.2 activations cascades events

Product Overview:
(±)-SKF 81297 is a selective agonist of the dopamine D1-like receptor (Ki = 1.9 nM).{24103} It demonstrates comparatively lower binding affinity for the dopamine D2, dopamine D3, serotonin 5-HT2A, and adrenergic α2 receptors (Kis = 1,272, >10,000, 955, and 509 nM, respectively).{24103} Activation of dopamine D1-like receptors by selective agonists such as (±)-SKF 81297 have been implicated in initiating a cascade of signaling events leading to reward-related incentive learning.{24104}

Size	5 mg
Shipping	dry ice
CAS Number	67287-39-2
Molecular Formula	C₁₆H₁₆ClNO₂ • HBr
SMILES	OC1=CC2=C(C(Cl)=C1O)CCNCC2C3=CC=CC=C3.Br
Molecular Weight	370,7
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2908.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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