Nifuroxazide

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Nifuroxazide

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Cat No: 18163

Nifuroxazide is a nitrofuran antibiotic.{54760} It is active against strains of the enteropathogenic bacteria C. jejuni, Salmonella, Y. enterocolitica, Shigella, and E. coli.{54760} It inhibits quorum sensing and virulence factor production in P. aeru...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-hydroxy-benzoic acid, 2-[(5-nitro-2-furanyl)methylene]hydrazide

Correlated keywords:

adral antinal bacifurane diarlidan dicoferin enterofuril ercefurol ercefuryl nifuroxazid pentofuryl RC-27109 RC27109 RC-30-109 RC30-109 nitrofuran RC30109 RC-27-109 27109 Campylobacter Yersinia Escherichia Pseudomonas STAT 3 U 266 INA6 MCF7 4 T1 MDAMB231 MDAMB MB231

Product Overview:
Nifuroxazide is a nitrofuran antibiotic.{54760} It is active against strains of the enteropathogenic bacteria C. jejuni, Salmonella, Y. enterocolitica, Shigella, and E. coli.{54760} It inhibits quorum sensing and virulence factor production in P. aeruginosa.{29336} Nifuroxazide inhibits STAT3 activity in a reporter assay (IC50 = ~3 µM) and decreases viability of U266 and INA-6 myeloma cells, which have constitutive STAT3 phosphorylation, with EC50 values of approximately 4.5 µM for both.{29334} It also decreases viability, migration, and invasion of, and induces apoptosis in, MCF-7, 4T1, and MDA-MB-231 breast cancer cells.{29337} Nifuroxazide (50 mg/kg per day) reduces tumor growth and prevents pulmonary metastasis in a 4T1 murine mammary carcinoma model. It also reduces diarrhea, weight loss, and colon inflammation in a rat model of acetic acid-induced ulcerative colitis.{54761}

Size	100 mg
Shipping	dry ice
CAS Number	965-52-6
Molecular Formula	C₁₂H₉N₃O₅
SMILES	OC1=CC=C(C(N/N=C/C2=CC=C([N+]([O-])=O)O2)=O)C=C1
Molecular Weight	275,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.