Fostriecin (sodium salt)

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Cat No: 14749

Biochemicals - Small Molecule Inhibitors

Fostriecin is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively).{23816,23817} It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM, respectively) and does not i...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(6R)-5,6-dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraen-1-yl]-2H-pyran-2-one, monosodium salt

Correlated keywords:

87810-56-8 96612-73-6 inhibitors phosphatases histones modifications epigenetics cancers PP2A PP4 proteins serine/threonine serine threonine H3 phosphorylation phosphorylates regulations cells proliferation proliferates antitumors anti-tumors anti tumors antibiotics CL 1565A sodium salts NSC 339638 NSC339638

Product Overview:
Fostriecin is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively).{23816,23817} It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM, respectively) and does not inhibit PP2B.{23816,21678} Through its effects on protein phosphatases, fostriecin increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation.{18481} On a related note, fostriecin was first identified as an antitumor antibiotic.{23815}

Size	100 µg
Shipping	dry ice
CAS Number	87860-39-7
Molecular Formula	C₁₉H₂₆O₉P • Na
SMILES	O=C1O[C@@H](/C=C/[C@@](C)(O)[C@H](OP([O-])(O)=O)C[C@@H](O)/C=C\C=C/C=C/CO)CC=C1.[Na+]
Molecular Weight	452,4
Formulation	A powder
Purity	≥95%
Custom Code	2932.99
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.