G3335

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G3335

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Cat No: 17593

Biochemicals - Receptor Pharmacology

Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor with key roles in adipocyte differentiation and glucose homeostasis.{18294,14553} G3335 is a cell-permeable dipeptide that potently antagonizes PPARγ (Kd = 8.34 µM).{28551} It r...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-tryptophyl-L-glutamic acid

Correlated keywords:

peptide neuroscience receptor antagonist nuclear signal transduction PPAR G 3335 tryptophylglutamic acid biochemical PPAR? PPAR-?

Product Overview:
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor with key roles in adipocyte differentiation and glucose homeostasis.{18294,14553} G3335 is a cell-permeable dipeptide that potently antagonizes PPARγ (Kd = 8.34 µM).{28551} It reversibly and competitively blocks activation of PPARγ by rosiglitazone (IC50 = 8-32 µM).{28551} G3335 is active in vivo, abolishing the protective effects of rosiglitazone in experimental spinal cord injury in rats.{28550} G3335 has also been used to evaluate the role of PPARγ in neurotoxicity studies.{28549,28552}

Size	10 mg
Shipping	dry ice
CAS Number	36099-95-3
Molecular Formula	C₁₆H₁₉N₃O₅
SMILES	OC(CC[C@@H](C(O)=O)NC([C@@H](N)CC1=CNC2=C1C=CC=C2)=O)=O
Molecular Weight	333,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2916.39
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.