BADGE

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BADGE

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Cat No: 70790

Biochemicals - Receptor Pharmacology

PPARγ is a ligand-activated transcription factor involved in the regulation of lipid homeostasis and may function as a master regulator of adipogenesis.{6619,2160,6620,4136} Ligands for PPARγ include antidiabetic drugs of the thiazolidinedione structur...

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About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis-oxirane

Correlated keywords:

1173097-76-1 Isopropylidenediphenol diglycidyl ether oxirane Bisphenol A-bisglycidyl bisoxiranyl Dian Diglycidyl diphenylolpropane Diglycidylbisphenol Diomethane Lapox A-16 A16 NSC5022 PPAR-? anti-diabetic 3T3L1 3T3F442A

Product Overview:
PPARγ is a ligand-activated transcription factor involved in the regulation of lipid homeostasis and may function as a master regulator of adipogenesis.{6619,2160,6620,4136} Ligands for PPARγ include antidiabetic drugs of the thiazolidinedione structural class, 15-deoxy-Δ12,14-prostaglandin J2 (Item No. 18570), and NSAIDS.{8461,7575,1424,4044} BADGE is a synthetic compound used in the production of polycarbonate and industrial plastics. This compound was recently identified as an antagonist of PPARγ.{8241} BADGE binds to PPARγ with an apparent Kd of 100 µM and interferes with the ability of 3T3-L1 and 3T3-F442A cells to undergo hormone-mediated cell differentiation.{8241}

Size	25 g
Shipping	dry ice
CAS Number	1675-54-3
Molecular Formula	C₂₁H₂₄O₄
SMILES	CC(C)(c1ccc(OCC2OC2)cc1)c1ccc(OCC2OC2)cc1
Molecular Weight	340,4
Formulation	A neat oil
Purity	≥85%
Custom Code	2910.90
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.