15(R)-17-phenyl trinor Prostagla

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15(R)-17-phenyl trinor Prostaglandin F_2? isopropyl ester

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Cat No: 16825

Biochemicals - Lipids

15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

9?,11?,15R-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid, isopropyl ester

Correlated keywords:

anaolg esters eyes intraocular hypotensive pressure lumigan bimatoprost 15(R)-17-phenyl-Prostaglandin F2.alpha.-iPr 15(R)-17-phenyl-Prostaglandin F2alpha-iPr 15(R)-17-phenyl-Prostaglandin F2a-iPr IOP 15(R)-13,14-dehydro Latanoprost prostaglandins ophthalmology glaucoma

Product Overview:
15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2α isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC50 values for the free acid forms of 15(S)-17-phenyl trinor PGF2α and 15(R)-17-phenyl trinor PGF2α were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle.{9736} A 3 µg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.{9736}

Size	1 mg
Shipping	dry ice
CAS Number	130273-87-9
Molecular Formula	C₂₆H₃₈O₅
SMILES	O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](/C=C/[C@H](O)CCC2=CC=CC=C2)[C@H](O)C1
Molecular Weight	430,6
Formulation	A solution in methyl acetate
Purity	≥98%
Custom Code	2937.50
UNSPSC code	12352100

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