17-phenyl trinor Prostaglandin F

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17-phenyl trinor Prostaglandin F_2? isopropyl ester

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Cat No: 16824

Biochemicals - Lipids

17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost.{8322} The N-ethyl amide prostaglandin prodrugs are converted to the...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

9?,11?,15S-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid, isopropyl ester

Correlated keywords:

analogs esters eyes intraocular hypotensive pressure lumigan bimatoprost 17-phenyl-trinor-PGF2.alpha.-iPr 17-phenyl-trinor-PGF2alpha-iPr 17-phenyl-trinor-PGF2a-iPr IOP prostaglandins ophthalmology glaucoma

Product Overview:
17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost.{8322} The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost.{8941} This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist.{9206} In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The 17-phenyl trinor PGF2α isopropyl ester derivative was examined for IOP-lowering activity during the development of latanoprost.{9311} At the dose of 3 μg/eye in the monkey, 17-phenyl trinor PGF2α isopropyl ester was the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative was also significantly more irritating to the eye than latanoprost.{9311}

Size	1 mg
Shipping	dry ice
CAS Number	130209-76-6
Molecular Formula	C₂₆H₃₈O₅
SMILES	O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1
Molecular Weight	430,6
Formulation	A solution in ethanol
Purity	≥98%
Custom Code	2937.50
UNSPSC code	12352100

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