A-443654

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A-443654

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Cat No: 16499

Biochemicals - Kinase Inhibitors

Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBα, β, γ) modulate cell proliferation, metabolism, and survival as well as angiogenesis. A-443654 is an inhibitor of Akt (Ki = 160 pmol/L for all three isoforms) ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

?S-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-1H-indole-3-ethanamine

Correlated keywords:

Akt1 Akt2 Akt3 proteins kinases B PKB cancers cells proliferation inhibitors biochemicals signals tranductions inhibits inhibitions Akt-1 Akt-2 Akt-3 Akts 1 2 3 PK A443654 A 443654 pan isoforms PKB? PKB? PKB? ? ? ? modulates metabolism survivals angiogenesis mitotic progressions bipolar spindles formations induces G2/M G2 M accumulations defects centrosomes separations monopolar arrays disorganized Akt-dependent dependent tumors in vivo mouses models phosphorylation Thr Thr308 308 Ser Ser473 473 humans lines mechanisms rapid feedback reactions

Product Overview:
Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBα, β, γ) modulate cell proliferation, metabolism, and survival as well as angiogenesis. A-443654 is an inhibitor of Akt (Ki = 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation.{26942,26944} It induces G2/M accumulation, defects in centrosome separation, and formation of either monopolar arrays or disorganized spindles.{26944} A-443654 has been reported to slow the progression of Akt-dependent tumors in in vivo mouse models.{26942} In response to an A-443654-induced decrease in phosphorylation of Akt targets, a concomitant increase in Thr308 and Ser473 phosphorylation of Akt has been observed in human cancer cell lines.{26943} A-443654 has been used to examine the mechanism of this rapid feedback reaction.

Size	500 µg
Shipping	dry ice
CAS Number	552325-16-3
Molecular Formula	C₂₄H₂₃N₅O
SMILES	N[C@@H](CC1=CNC2=C1C=CC=C2)COC3=CC(C4=CC(C(C)=NN5)=C5C=C4)=CN=C3
Molecular Weight	397,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.19
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.