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GDC-0941

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    GDC-0941
  • GDC-0941
Cat No: 11600
Biochemicals - Kinase Inhibitors
Cayman
€157.00
Price is excluding VAT and does not include packaging neither shipping

The phosphatidylinositol 3-kinase (PI3K) signaling pathway has central roles in cell growth, development, and survival.{13740,17822} GDC-0941 is a potent pan inhibitor of class I catalytic subunits of PI3K, inhibiting p110α, β, δ, and γ with IC50 value...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine
Correlated keywords:
  • 1146702-​55-​7 inhibitors signals transductions cancers kinases GDCs 0941 GDC0941 GDC-0341 pan inhibits inhibitions class I isoforms phosphatidylinositol-3-kinase phosphatidylinositol 2 three catalytic subunits p110 blockage Akt GNEs GNE-0941 GNE0941 pictilisib pictrelisib
Product Overview:
The phosphatidylinositol 3-kinase (PI3K) signaling pathway has central roles in cell growth, development, and survival.{13740,17822} GDC-0941 is a potent pan inhibitor of class I catalytic subunits of PI3K, inhibiting p110α, β, δ, and γ with IC50 values of 3, 33, 3, and 75 nM, respectively.{24602,24604} It is much less effective against class II-IV isoforms of PI3K and against mTOR.{24602,24603} GDC-0941 inhibits the growth of certain types of cancer cells and blocks signaling through PI3K to Akt, both in cells and in vivo.{24602,24605}
Size 10 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 957054-30-7
Molecular Formula C23H27N7O3S2
SMILES CS(N(CC1)CCN1CC(S2)=CC3=C2C(N4CCOCC4)=NC(C5=C(C=NN6)C6=CC=C5)=N3)(=O)=O
Molecular Weight 513,6
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.59
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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