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GDC-0068

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    GDC-0068
  • GDC-0068
Cat No: 18412
Biochemicals - Kinase Inhibitors
Cayman

GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays.{30936} It is 620-fold selective for Akt over protein kinase A and has been shown to block Ak...

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This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • (2S)-?(4-?chlorophenyl)?-?1-?[4-?[(5R,?7R)?-?6,?7-?dihydro-?7-?hydroxy-?5-?methyl-?5H-?cyclopentapyrimidin-?4-?yl]?-?1-?piperazinyl]?-?3-?[(1-?methylethyl)?amino]?-1-?propanone
Correlated keywords:
  • 1417449-25-2 1396257-94-5 1489263-16-2 GDC0068 RG7440 pan-Akt Akt1/2/3 panAkt Akt1 Akt2 Akt3 Akt-1 Akt-2 Akt-3 GDC68 GDC-68
Product Overview:
GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays.{30936} It is 620-fold selective for Akt over protein kinase A and has been shown to block Akt signaling selectively in cultured tumor cell lines characterized by activated Akt, halting cell cycle progression and reducing cell viability.{30936} In multiple tumor xenograft models, oral administration of GDC-0068 at 100 mg/kg/day can lead to delayed tumor growth and regression.{30936}
Size 1 mg
Shipping dry ice
CAS Number 1001264-89-6
Molecular Formula C24H32ClN5O2
SMILES ClC1=CC=C([C@H](C(N2CCN(C3=NC=NC4=C3[C@H](C)C[C@H]4O)CC2)=O)CNC(C)C)C=C1
Molecular Weight 458
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.59
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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