PKG Inhibitor

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PKG Inhibitor

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Cat No: 15995

Biochemicals - Kinase Inhibitors

PKG inhibitor is a specific cGMP-dependent PKG inhibitor (Ki = 86 µM).{26244} This synthetic peptide is a nonphosphorylatable analog of a substrate corresponding to the serine-32 phosphorylation site in histone H2B.{26244} PKG inhibitor has been repor...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-arginyl-L-lysyl-L-arginyl-L-alanyl-L-arginyl-L-lysyl-L-glutamic acid

Correlated keywords:

inhibitors inhibits inhibitions cGMP cyclic GMP-dependent proteins kinases PKG peptides histones H2B phosphorylation nonphosphorylatable synthetics peptides analogs analogous serine-32 serines 32 sites histones H2B cGMP-dependent NMDA GABA nucleotides intracellular signaling neuroscience signals transduction Arg-Lys-Arg-Ala-Arg-Lys-Glu

Product Overview:
PKG inhibitor is a specific cGMP-dependent PKG inhibitor (Ki = 86 µM).{26244} This synthetic peptide is a nonphosphorylatable analog of a substrate corresponding to the serine-32 phosphorylation site in histone H2B.{26244} PKG inhibitor has been reported to block cGMP-dependent NMDA potentiation and nitric oxide-induced depression of GABA currents in cultured retinal amacrine cells.{26245}

Size	1 mg
Shipping	dry ice
CAS Number	82801-73-8
Molecular Formula	C₃₈H₇₄N₁₈O₁₀
SMILES	O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)N)=O)CCCCN)=O)CCCNC(N)=N)=O)C)=O)CCCNC(N)=N)=O)CCCCN)N[C@@H](CCC(O)=O)C(O)=O
Molecular Weight	943,1
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.