H-8 (hydrochloride)

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H-8 (hydrochloride)

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Cat No: 10010249

Biochemicals - Kinase Inhibitors

The H series isoquinolinesulfonamide protein kinase (PK) inhibitors are widely used to block signaling pathways to elucidate mechanisms of cellular regulation and signal transduction. H-8, an isoquinolinesulfonamide protein kinase (PK) inhibitor, is a ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide, dihydrochloride

Correlated keywords:

PKA PKG PKC MLCK cyclin C Cdk8 cyclin H Cdk7 p36 signal transduction inhibitor inhibits inhibition transcription 84478-11-5

Product Overview:
The H series isoquinolinesulfonamide protein kinase (PK) inhibitors are widely used to block signaling pathways to elucidate mechanisms of cellular regulation and signal transduction. H-8, an isoquinolinesulfonamide protein kinase (PK) inhibitor, is a potent inhibitor of PKA and PKG and shows moderate inhibition for PKC and MLCK with Ki values of 1.2, 0.48, 15, and 68 µM, respectively.{16039,16079,16080} H-8 can disrupt transcriptional elongation by inhibiting cyclin C/Cdk8 and cyclin H/Cdk7/p36 CTD kinase activity with IC50 values of 47 and 6.2 µM, respectively.{15207}

Size	5 mg
Shipping	dry ice
CAS Number	113276-94-1
Molecular Formula	C₁₂H₁₅N₃O₂S • 2HCl
SMILES	CNCCNS(C1=CC=CC2=CN=CC=C21)(=O)=O.Cl.Cl
Molecular Weight	338,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.49
UNSPSC code	12352100

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MSDS

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