HA-1004 (hydrochloride)

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Cat No: 10010558

Biochemicals - Kinase Inhibitors

HA-1004 is an inhibitor of protein kinase G (PKG) and PKA (Kis = 1.4 and 2.3 µM, respectively).{48086} It also inhibits PKC and blocks intracellular calcium mobilization.{48087,48088} HA-1004 induces relaxation of isolated rabbit aortic strips precont...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[2-[(aminoiminomethyl)amino]ethyl]-5-isoquinolinesulfonamide, dihydrochloride

Correlated keywords:

91742-10-8 HA1004 A-23187 PGF2?

Product Overview:
HA-1004 is an inhibitor of protein kinase G (PKG) and PKA (Kis = 1.4 and 2.3 µM, respectively).{48086} It also inhibits PKC and blocks intracellular calcium mobilization.{48087,48088} HA-1004 induces relaxation of isolated rabbit aortic strips precontracted with histamine, serotonin (Item No. 14332), A23187 (Item No. 11016), angiotensin II (Item No. 17150), or prostaglandin F2α (Item No. 16010; EC50s = 0.32-0.63 µM), as well as phenylephrine (Item Nos. 18619
17205) with or without calcium (EC50s = 2.3 and 0.5 µM, respectively). It also inhibits histamine-induced bronchoconstriction in guinea pigs without affecting blood pressure when administered intratracheally at a dose of 0.1 mg per animal.{48087}

Size	5 mg
Shipping	dry ice
CAS Number	92564-08-4
Molecular Formula	C₁₂H₁₅N₅O₂S • 2HCl
SMILES	O=S(C1=CC=CC2=CN=CC=C21)(NCCNC(N)=N)=O.Cl.Cl
Molecular Weight	366,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2935.90
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.