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L-Phenylephrine

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    L-Phenylephrine
  • L-Phenylephrine
Cat No: 17205
Biochemicals - Receptor Pharmacology
Cayman

L-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 µM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 µM, respectively).{28120} By stimulating adrenergic α1 receptors, L-phenylephrine can indu...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 3-hydroxy-?R-[(methylamino)methyl]-benzenemethanol
Correlated keywords:
  • adrenergic ?1A receptor agonist contraction vascular endothelium smooth muscle vasocontraction hypertension decongestant disease biochemical ?1B ?1C subtype induce aortic L-norepinephrine precontract vasodilator agent arteriole nasal mucosa constriction oral oxedrine synephrine (-)-phenylephrine (R)-phenylephrine L-phenylephedrine mesaton mesatone metaoxedrin metaoxedrine metasympatol metasynephrine mezaton neo-synephrine phenylephrine mezaton visadron pxedrine sympathol sympatol synephrine neosynephrine
Product Overview:
L-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 µM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 µM, respectively).{28120} By stimulating adrenergic α1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine.{28119} This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents.{28121,28122} Because L-phenylephrine acts on adrenergic α1 receptors in the arterioles of the nasal mucosa to produce constriction, it has been examined clinically as an oral decongestant.{28123}
Size 500 mg
Shipping dry ice
CAS Number 59-42-7
Molecular Formula C9H13NO2
SMILES OC1=CC=CC([C@@H](O)CNC)=C1
Molecular Weight 167,2
Formulation A crystalline solid
Purity ≥98%
Custom Code 2907.19
UNSPSC code 12352100

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Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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