Disulfiram

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Disulfiram

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Cat No: 15303

Biochemicals - Small Molecule Inhibitors

Disulfiram is a copper and zinc chelator and an irreversible inhibitor of aldehyde dehydrogenase (IC50 = 0.1 mM).{25186} It also inhibits the copper-dependent enzyme dopamine β-hydroxylase, which prevents the breakdown of dopamine and has been conside...

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Territorial Availability: Available through Bertin Technologies only in France

                                            Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.
                    

Special Advice: Dangerous Good in said quantity, not available for sale.

Synonyms:

N,N,N',N'-tetraethyl-thioperoxydicarbonic diamide

Correlated keywords:

155-?01-?1 11078-?22-?1 Antabuse Antabus alcoholism alcohol abuse dependence metabolism anti-cancer anti cancers anticancers metal chelator copper zinc 20S proteasome 26S proteasome cocaine inhibitors inhibits inhibitions aldehydes dehydrogenase dopamine ?-hydroxylase irreversible b-hydroxylase beta-hydroxylase .beta.-hydroxylase MDA-MB-0231 MDAMB0231 MDA MB 0231 breast reactive oxygen species ROS JNK p38 NF-kB NF-?B NF-kappaB NF-.kappa.B stem cells abstensil abstinil abstinyl accel TET TET-R TETR R akrochem TETD alcophobin antadix antaethyl antalcol antetan antetil anticol antietanol antietil antikol antivitium aversan averzan contralin cronetal dicupral ekagom DTET TEDS TETDS espenal etabus ethyl thiram thiurad tuads tuex etiltox exhoran exhorran hoca krotenal tetraethyldithiuram disulfide NSCs 25953 NSC-25953 NSC25953 nocceler TET-G TETG G noxal refusal sanceler soxinol stopetyl TTs tetradin tetradine tetraethyldithiuram tetraethylthioperoxydicarbonic diamide tetraethylthiram tetraethylthiuram tetraetil teturam teturamin thiuram E thiuranide

Product Overview:
Disulfiram is a copper and zinc chelator and an irreversible inhibitor of aldehyde dehydrogenase (IC50 = 0.1 mM).{25186} It also inhibits the copper-dependent enzyme dopamine β-hydroxylase, which prevents the breakdown of dopamine and has been considered as a treatment for cocaine dependence.{25185} When in complex with copper, disulfiram has been shown to inhibit purified 20S proteasome (IC50 = 7.5 μM) and 26S proteasome (IC50 = 20 μM) from MDA-MB-0231 breast cancer cells.{25183,25182} Because disulfiram targets the ubiquitin-proteasome pathway, it has been investigated as an anti-cancer agent. Furthermore, at 250 nM it has been shown to induce reactive oxygen species, to activate JNK and p38 pathways, and to inhibit NF-κB activity, which suppresses self-renewal in cancer stem cells.{25187,25184}

Size	100 g
Shipping	room temp.
CAS Number	97-77-8
Molecular Formula	C₁₀H₂₀N₂S₄
SMILES	S=C(N(CC)CC)SSC(N(CC)CC)=S
Molecular Weight	296,5
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2930.90
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.