Acamprosate (calcium salt)

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Cat No: 23899

Biochemicals - Ion Channel Modulation

Acamprosate is an acetylated derivative of the GABA analog homotaurine (tramiprosate; Item No. 20701).{36372} Despite its structural similarity to GABA, acamprosate does not act at GABAA receptors but does decrease paired-pulse inhibition of GABAA inh...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-(acetylamino)-1-propanesulfonic acid, hemicalcium salt (2:1)

Correlated keywords:

77337-76-9 alcomed aotal Ca-AOTA bisacetyl homotaurine campral EC regtect sobriol N-acetyl Homotaurinate acetylhomotaurinate GABA-A B Ca-AOTA CaAOTA Campral EC Regtect Sobriol

Product Overview:
Acamprosate is an acetylated derivative of the GABA analog homotaurine (tramiprosate; Item No. 20701).{36372} Despite its structural similarity to GABA, acamprosate does not act at GABAA receptors but does decrease paired-pulse inhibition of GABAA inhibitory post-synaptic currents (IPSCs) at short inter-stimulus intervals when used at a concentration of 300 µM, indicating that it may inhibit GABAB autoreceptor-mediated inhibition of GABA release.{36373,36371,36374} It is an NMDA receptor modulator with antagonist or agonist effects depending on brain region, receptor subunit composition, and other factors.{36374} Acamprosate (0.26 and 0.52 mmol/kg per day, i.p.) reduces voluntary intake of ethanol in rats, an effect that can be blocked by the GABA antagonist bicuculline (Item No. 11727). Formulations containing acamprosate have been used for the maintenance of alcohol abstinence.

Size	100 mg
Shipping	dry ice
CAS Number	77337-73-6
Molecular Formula	C₅H₁₀NO₄S • 1/2Ca
SMILES	[O-]S(CCCNC(C)=O)(=O)=O.[O-]S(CCCNC(C)=O)(=O)=O.[Ca+2]
Molecular Weight	200,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.