Bicuculline

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Bicuculline

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Cat No: 11727

Biochemicals - Ion Channel Modulation

Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influence on target neurons. These receptors are the major targets for benzodiazepines and related ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-(6R)-furo[3,4-e]-1,3-benzodioxol-8(6H)-one

Correlated keywords:

bicucullin bucuculline GABA GABAA receptors antagonists epilepsy chloride channels neurosciences retinal neurobiology receptive fields allosteric inhibits inhibitors inhibitions cortical neurons blocks brains slices

Product Overview:
Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influence on target neurons. These receptors are the major targets for benzodiazepines and related anxiolytic drugs.{18157} Bicuculline is a competitive GABAA receptor antagonist that can act as an allosteric inhibitor at GABAA receptors.{21007,21009} At 100 μM, it blocks spontaneously opening chloride channels in the outside-out patches from the cultured cortical neurons.{21009} Bicuculline also reversibly blocks GABAA receptors on horizontal cells in the mouse retina with an IC50 value of 1.7 μM.{21010} By blocking the inhibitory action of GABA, bicuculline mimics the action of epilepsy and is widely used in experimental studies as a convulsant, inducing seizure in hippocampal or cortical neurons in prepared brain slices.{21008}

Size	50 mg
Shipping	dry ice
CAS Number	485-49-4
Molecular Formula	C₂₀H₁₇NO₆
SMILES	CN1[C@@]([C@@]2([H])C(C=CC3=C4OCO3)=C4C(O2)=O)([H])C5=CC6=C(OCO6)C=C5CC1
Molecular Weight	367,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2939.79
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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